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Ris-Stalpers C, Kuiper GG, Faber PW, Schweikert HU, van Rooij HC, Zegers ND, Hodgins MB, Degenhart HJ, Trapman J, Brinkmann AO

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The precise saturation point for Ipamorelin in humans was never established in an approval-grade trial, and applying a single per-kilogram number across subjects ignores substantial inter-individual variability in GH responsiveness

Clinical studies (Deng et al., 2021) have shown an elevated KYN/Trp ratio in patients with depression, with similar metabolic disturbances observed in epilepsy, further suggesting a substantial role of this pathway in EDC